Accelerated Failure Time Model

Accelerated Failure Time ModelWhereas a proportional hazards model presumes that the impact of a covariate is to increase the hazard by some constant, an AFT model assumes that the impact of a covariate is to decelerate or accelerate the life span of a disease by a few constant.

This is specifically appealing in a technical context in which the disease is an outcome of some mechanical procedure with a known sequence of intermediary levels.

Statistical issues:

As opposed to proportional hazards models, where Cox's semi parametric proportional hazards model is more broadly used compared to parametric models, AFT models are predominately completely parametric i.e. a probability distribution is specified with regard to log(T0).

Weibull Accelerated Failure Time Model

The data were analyzed making use of a Weibull model with the accelerated failure time parameterisation, since this is the parameterisation which refers to g-estimation (i.e., calculating the survival ratio instead of the hazard ratio).

The accelerated failure time model presumes for that individual failure times Ti with covariates xi that:

T i = exp  (đ T x i + e i )

Where ei features a standard extreme value distribution with scale parameter 1/g , in which g is the shape parameter. Survival models such as current smoking, current smoking and blood pressure, baseline smoking and current smoking and blood pressure and smoking and blood pressure at current and previous visits, were all fitted. The model such as current smoking only estimated the survival time ratio with regard to smokers compared to nonsmokers as 1.14 (95% CI 1.06–1.23), concluding that smoking had small impact on survival.

Survival Models and Data Analysis

Survival analysis is a department of statistics which handles analysis of time duration to until a number of events happen, including failure in mechanical systems and death in biological organisms. This topic is known as reliability analysis or reliability theory in engineering and duration modeling or duration analysis in economics or event history analysis within sociology. Survival analysis tries to answer questions including: what is the proportion of a population which will survive past a certain time? Of those that survive, at what rate will they fail or die? Can numerous causes of death or failure be taken into account? How do particular characteristics or circumstances decrease or increase the probability of survival?

Data Analysis is the procedure of systematically using statistical and/or logical methods to illustrate and describe, recap and condense and evaluate data. Based on Shamoo and Resnik different analytic procedures give a way of drawing inductive inferences through data and distinguishing the signal (the phenomenon of attention) from the noise (statistical fluctuations) existing in the data.

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