After getting treated with high dose anticancer medicines and/or radiation, the sufferer receives the harvested stem cells, which travel to the bone marrow and start to generate new blood cells.
A mini transplant makes use of lower, less toxic doses of chemotherapy and/or radiation to get ready the patient for transplant.
A tandem transplant requires two sequential programs of stem cell transplant and high dose chemotherapy.
Bone marrow and hematopoietic stem cells:
Bone marrow is the soft, sponge such as material found inside bones. It has immature cells called blood-forming stem cells or hematopoietic. (Hematopoietic stem cells are various from embryonic stem cells. Embryonic stem cells can develop into every kind of cell in your body.)
Hematopoietic stem cells divide to make more blood-forming stem cells or they mature into one of three kinds of blood cells: red blood cells, which carry oxygen; platelets, which aid the blood to clot and white blood cells, which fight infection.
Bone marrow transplantation is actually a procedure where stem cells through bone marrow that generate various blood cells such as white blood cells, red blood cells and platelets are injected into a receiver.
These stem cells are also known as hematopoietic stem cells. Today, hematopoietic stem cells may be also obtained through peripheral blood after therapy with certain progress factors or from umbilical cord. Therefore, the word Hematopoietic stem cell transplantation is currently preferred to Bone marrow transplantation to contain these other sources of hematopoietic stem cells.
The bone marrow is a soft, spongy portion inside a bone. It includes immature cells referred to as stem cells that have a constant ability to create different kinds of blood cells i.e. white blood cells, red blood cells and platelets. These are launched into the blood stream. Bone marrow is of two types yellow marrow and red marrow.
In the bone marrow, there is around one stem cell in each 100,000 blood cells. The bone marrow in the breast bone, hips, skull, ribs and spine provides the stem cells.
In the blood stream, the number of stem cells is approximately 1/100 of that in the bone marrow. Transplantation of these stem cells through the blood stream is occasionally utilized in addition to or instead of, traditional bone marrow transplantation.
A bone marrow transplant is done by transferring stem cells from one individual to another. Stem cells either can be collected through the circulating cells in the blood (the peripheral system) or from the bone marrow.